Host response to a dam mutant of Salmonella enterica serovar enteritidis with a temperature-sensitive phenotype.

نویسندگان

  • Mónica N Giacomodonato
  • Sebastián H Sarnacki
  • Roberto L Caccuri
  • Daniel O Sordelli
  • M Cristina Cerquetti
چکیده

The temperature-sensitive dam mutant strain of Salmonella enterica serovar Enteritidis SD1 is highly attenuated and induces innate and protective immunity in mice. SD1 activates NF-kappaB and induces gamma interferon secretion. Early interaction of the SD1 mutant with intestinal epithelial cells was associated with ruffling of enterocytes. Invading bacteria were found inside Peyer's patches after inoculation.

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عنوان ژورنال:
  • Infection and immunity

دوره 72 9  شماره 

صفحات  -

تاریخ انتشار 2004